frontiers | source of chronic inflammation in aging
aging is a complex process that results from a combination of environmental, genetic, and epigenetic factors. a chronic pro-inflammatory status is a pervasiv...
redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept
age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. however, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. a more comprehensive view of age-related inflammation, that has a scope beyond the conventional view, is therefore required. in this review, we discuss newly emerging data on multi-phase inflammatory networks and proinflammatory pathways as they relate to aging. we describe the age-related upregulation of nuclear factor (nf)-κb signaling, cytokines/chemokines, endoplasmic reticulum (er) stress, inflammasome, and lipid accumulation. the later sections of this review present our expanded view of age-related senescent inflammation, a process we term “senoinflammation”, that we propose here as a novel concept. as described in the discussion, senoinflammation provides a schema highlighting the important and ever-increasing roles of proinflammatory senescence-associated secretome, inflammasome, er stress, tlrs, and micrornas, which support the senoinflammation concept. it is hoped that this new concept of senoinflammation opens wider and deeper avenues for basic inflammation research and provides new insights into the anti-inflammatory therapeutic strategies targeting the multiple proinflammatory pathways and mediators and mediators that underlie the pathophysiological aging process.
inflammation and aging: signaling pathways and intervention therapies - signal transduction and targeted therapy
aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. given the multidimensional complexity of aging, there is an urgent need for a systematic organization of inflammaging through dimensionality reduction. factors secreted by senescent cells, known as the senescence-associated secretory phenotype (sasp), promote chronic inflammation and can induce senescence in normal cells. at the same time, chronic inflammation accelerates the senescence of immune cells, resulting in weakened immune function and an inability to clear senescent cells and inflammatory factors, which creates a vicious cycle of inflammation and senescence. persistently elevated inflammation levels in organs such as the bone marrow, liver, and lungs cannot be eliminated in time, leading to organ damage and aging-related diseases. therefore, inflammation has been recognized as an endogenous factor in aging, and the elimination of inflammation could be a potential strategy for anti-aging. here we discuss inflammaging at the molecular, cellular, organ, and disease levels, and review current aging models, the implications of cutting-edge single cell technologies, as well as anti-aging strategies. since preventing and alleviating aging-related diseases and improving the overall quality of life are the ultimate goals of aging research, our review highlights the critical features and potential mechanisms of inflammation and aging, along with the latest developments and future directions in aging research, providing a theoretical foundation for novel and practical anti-aging strategies.
inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
most older individuals develop inflammageing, a condition characterized by elevated levels of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability, frailty, and premature death. potential mechanisms of ...
source of chronic inflammation in aging
aging is a complex process that results from a combination of environmental, genetic, and epigenetic factors. a chronic pro-inflammatory status is a pervasive feature of aging. this chronic low-grade inflammation occurring in the absence of overt ...
inflammaging: what you should know about inflammation and aging | brown university health
inflammation is a normal response by your body but as we age, chronic inflammation, known as inflammaging, can increase the risk of
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